Small cell B-cell lymphoma

The group of small cell B-cell lymphomas accounts for approximately half of all B-cell lymphomas. Although most of the small cell B-cell lymphomas can be classified reliably, difficult differential diagnoses remain. This review discusses the pathological diagnosis of the most common small B-cell lymphomas in the lymph node. Remaining differential diagnostic difficulties are discussed in relation to recent research efforts that are or might become helpful to resolve these remaining difficulties. Particular attention is paid to large-scale sequencing efforts and their effect on our understanding of disease pathogenesis and their value for both diagnosis and prognosis.