Is Water Diffusion Isotropic in the Cirrhotic Liver? A Study with Diffusion-weighted Imaging at 3.0 Tesla

The liver shows isotropic water diffusion in cirrhotics, despite fibrotic distortion leading to decreased ADC as compared to controls. Our results emphasize that the correlation between parenchymal changes in liver fibrosis and the ADC estimate remains an elusive goal based on the state-of-the-art DWI technique.