In Vivo Lipid Profiling Using Proton Magnetic Resonance Spectroscopy in an Experimental Liver Fibrosis Model

The hepatic lipid changes in CCl4-induced experimental fibrosis model were documented in vivo and longitudinally using 1H MRS at 7 Tesla. The experimental findings suggested that total saturated fatty acid increase contributed mainly to the total lipid increase in animals with CCl4 insult. This study also demonstrated the potential value of high field MRS to resolve lipid composition and alterations in liver fibrosis.