T1 Relaxivity of Core-encapsulated Gadolinium Liposomal Contrast Agents-Effect of Liposome Size and Internal Gadolinium Concentration

The size of CE-Gd liposomal nanoparticles significantly affects the T1 relaxivity. An inverse relation was observed between liposome size and T1 relaxivity. The T1 relaxivity did not change significantly with core Gd concentration over the measured concentration range.