The diagnostic value of dual phase FDG PET CT in grading of gliomas

ObjectiveThe purpose of this study was to investigate the correlation between the FDG PET CT and histopathology in grading of gliomas.Methods16 patients with clinically diagnosed glioma performed dual phase FDG PET CT of the brain for staging, and the staging was correlated to the histopathological classification in the surgical specimen.ResultsWe found good correlation between the dual phase PET CT grading and the histopathological grading of gliomas, when a 23% increase was used as the cutoff for analysis of the difference in SUVmax of the lesion (L) versus normal gray matter (GM) over time, the sensitivity was 88.9%, the specificity was 85.7%, and the accuracy was 89.4% (P = 0.003; AUC = 0.94).ConclusionDual phase FDG PET CT is a reliable predictor of proliferative activity of gliomas and could be used as a method of grading of the tumor.