A potential role of CT perfusion parameters in grading of brain gliomas

Background and purposeGliomas are very heterogeneous tumors, glioma grading is currently based on the histologic assessment. With noninvasive measurement of vascular permeability by CT Perfusion (CTP) multiple perfusion parameters which can be obtained with a single acquisition the aim of this study was to find the most sensitive and specific CTP parameters and their cutoffs that can be used to differentiate between low and high grade brain gliomas.Material and methodsTwenty-five patients were included in this study divided into two groups: group A includes 15 patients with high grade glioma, group B includes 10 patients with low grade glioma; CTP was done for all patients, perfusion values of tumors were then calculated, and statistical analysis was done using IBM SPSS.ResultsA statistically highly significant difference was found between the two groups regarding the BF, BV and PS with P values of 0.0003, 0.00026 and 0.0009 respectively. The two groups were found to be self-discriminated by BV and PS with sensitivity of 95% and 86% respectively.ConclusionCTP shows high sensitivity in terms of differentiation between high and low grade adult gliomas.