Invasive mole of the uterus: A description of two cases managed by hysterectomy

Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumors. Gestational trophoblastic neoplasia (GTN), is recognized as the most curable gynecologic malignancy. However, many cases are resistant to first line chemotherapy. We present cases of invasive mole. They were diagnosed as a vesicular mole on ultrasonography and underwent suction and evacuation but vaginal bleeding recurred with plateau and rising B-hcg with intramyometrial vascular lesion. Hysterectomy was done that indicated invasive mole. Patients were cured of their symptoms. Surgical therapy (hysterectomy) with chemotherapy has shown to achieve remission in these cases especially with resistance to chemotherapy and in perimenopause.