کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4225166 | 1609749 | 2015 | 9 صفحه PDF | دانلود رایگان |

• MR-Imaging characteristics of hepatocellular tumors in the non-cirrhotic liver show significant differences.
• Independent MRI-features of HCC are T1-hypointensity, T2-hypo-/hyperintensity, lack of central-enhancement, satellite-lesions and lack of liver specific contrast media uptake.
• Reproducibility and diagnostic performance of HCC specific features are good.
• Change of diagnostic paradigm has the potential to reduce unnecessary surgery.
PurposeTo determine MR-imaging features for the differentiation between hepatocellular carcinoma (HCC) and benign hepatocellular tumors in the non-cirrhotic liver.Material and Methods107 consecutive patients without liver cirrhosis (46 male; 45 ± 14 years) who underwent liver resection due to suspicion of HCC were included in this multi-center study. The following imaging features were assessed: lesion diameter and demarcation, satellite-lesions, central-scar, capsule, fat-content, hemorrhage, vein-infiltration and signal-intensity (SI) on native T1-, T2- and dynamic-enhanced T1-weighted images (center versus periphery). In addition, contrast-media (CM) uptake in the liver specific phase was analyzed in a sub-group of 42 patients.ResultsSignificant differences between HCC (n = 55) and benign lesions (n = 52) were shown for native T1-, T2- and dynamic-enhanced T1-SI, fat-content, and satellite-lesions (all, P < .05). Independent predictors for HCC were T1-hypointensity (odds-ratio, 4.81), T2-hypo-/hyperintensity (5.07), lack of central tumor-enhancement (3.36), and satellite-lesions (5.78; all P < 0.05). Sensitivity and specificity of HCC was 91% and 75% respectively for two out-of four independent predictors, whereas specificity reached 98% for all four predictors. Sub-analysis, showed significant differences in liver specific CM uptake between HCC (n = 18) and benign lesions (n = 24; P < 0.001) and revealed lack of liver specific CM uptake (odds-ratio, 2.7) as additional independent feature for diagnosis of HCC.ConclusionIndependent MRI features indicating HCC are T1-hypointensity, T2-hypo- or hyperintensity, lack of central tumor-enhancement, presence of satellite-lesions and lack of liver specific CM-uptake. These features may have the potential to improve the diagnosis of HCC in the non-cirrhotic liver.
Journal: European Journal of Radiology - Volume 84, Issue 10, October 2015, Pages 1879–1887