کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4226114 1609787 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mapping the brain in type II diabetes: Voxel-based morphometry using DARTEL
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی رادیولوژی و تصویربرداری
پیش نمایش صفحه اول مقاله
Mapping the brain in type II diabetes: Voxel-based morphometry using DARTEL
چکیده انگلیسی

PurposeTo investigate the pattern of brain volume changes of the brain in patients with type II diabetes mellitus using voxel-based morphometry.Material and methodsInstitutional ethics approval and informed consent were obtained. VBM based on the high resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MRI images was obtained from 16 type II diabetes patients (mean age 61.2 years) and 16 normal controls (mean age 59.6 years). All images were spatially preprocessed using Diffeomorphic Anatomical Registration using Exponentiated Lie algebra (DARTEL) algorithm, and the DARTEL templates were made from 100 normal subjects. Statistical parametric mapping was generated using analysis of covariance (ANCOVA).ResultsAn atrophy pattern of gray matter was seen in type II diabetes patients compared with controls that involved the right superior, middle, and inferior temporal gyri, right precentral gyrus, and left rolandic operculum region. The loss of white matter volume in type II diabetes mellitus was observed in right temporal lobe and left inferior frontal triangle region. ROI analysis revealed that the gray and white matter volume of right temporal lobe were significant lower in type II diabetes mellitus than that in controls (P < 0.05).ConclusionThis work demonstrated that type II diabetes mellitus patients mainly exhibited gray and white matter atrophy in right temporal lobe, and this finding supported that type II diabetes mellitus could lead to subtle diabetic brain structural changes in patients without dementia or macrovascular complications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Radiology - Volume 81, Issue 8, August 2012, Pages 1870–1876
نویسندگان
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