کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4226384 | 1609799 | 2011 | 4 صفحه PDF | دانلود رایگان |
PurposeThe purpose of this study was to assess the apparent diffusion coefficient (ADC) of neuroblastic tumours and to evaluate if the ADC can enable differentiation of neuroblastoma and ganglioneuroma/ganglioneuroblastoma.Patients and methods16 histologically classified tumours (10 neuroblastomas and 6 ganglioneuroma/ganglioneuroblastoma) were investigated in 15 children. Diffusion-weighted echo-planar imaging was performed with a b-value of 800 s/mm2. The contrast of tumour tissue depicted with T2-weighted images and diffusion-weighted images was evaluated by means of region-of-interest (ROI) measurements and a calculation of the ADC by a software tool. The ADC of the psoas-muscle was measured to establish an internal standard, too.ResultsThe mean ADC of the 10 neuroblastomas was 0.81 × 10−3 mm2/s (SD 0.29 × 10−3 mm2/s, range 0.39–1.47 × 10−3 mm2/s). The mean ADC of the four ganglioneuroma and two ganglioneuroblastoma was 1.6 × 10−3 mm2/s (SD 0.340 × 10−3 mm2/s, range 1.13–1.99) × 10−3 mm2/s. The difference was significant in the t-test (p = 0.01). We found no ganglioneuroma or ganglioneuroblastoma with an ADC below 1.1 × 10−3 mm2/s.DiscussionThere is a significant difference of the ADC of neuroblastoma compared to the ADC of ganglioneuroma/ganglioneuroblastoma. These first results suggest that the diffusion-weighted imaging could differentiate neuroblastoma and ganglioneuroma/ganglioneuroblastoma by calculating the ADC.
Journal: European Journal of Radiology - Volume 79, Issue 3, September 2011, Pages 443–446