کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4226931 1609801 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantitative diffusion tensor deterministic and probabilistic fiber tractography in relapsing–remitting multiple sclerosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی رادیولوژی و تصویربرداری
پیش نمایش صفحه اول مقاله
Quantitative diffusion tensor deterministic and probabilistic fiber tractography in relapsing–remitting multiple sclerosis
چکیده انگلیسی

PurposeOur aim was to study the quantitative fiber tractography variations and patterns in patients with relapsing–remitting multiple sclerosis (RRMS) and to assess the correlation between quantitative fiber tractography and Expanded Disability Status Scale (EDSS).Material and methodsTwenty-eight patients with RRMS and 28 age-matched healthy volunteers underwent a diffusion tensor MR imaging study. Quantitative deterministic and probabilistic fiber tractography were generated in all subjects. And mean numbers of tracked lines and fiber density were counted. Paired-samples t tests were used to compare tracked lines and fiber density in RRMS patients with those in controls. Bivariate linear regression model was used to determine the relationship between quantitative fiber tractography and EDSS in RRMS.ResultsBoth deterministic and probabilistic tractography's tracked lines and fiber density in RRMS patients were less than those in controls (P < .001). Both deterministic and probabilistic tractography's tracked lines and fiber density were found negative correlations with EDSS in RRMS (P < .001). The fiber tract disruptions and reductions in RRMS were directly visualized on fiber tractography.ConclusionChanges of white matter tracts can be detected by quantitative diffusion tensor fiber tractography, and correlate with clinical impairment in RRMS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Radiology - Volume 79, Issue 1, July 2011, Pages 101–107
نویسندگان
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