کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4226984 | 1609812 | 2010 | 5 صفحه PDF | دانلود رایگان |

Background18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is commonly used to distinguish benign from malignant lesion. Recently, maximum standardized uptake value (SUVmax) on FDG-PET has found to have prognostic value. We examined the relationship between SUVmax and proliferative activities as indicated by maximum diameter of tumor opacity on mediastinal-window images (TOM), Ki-67 index, and diameter of the pathological invasive area in lung adenocarcinomas ≤30 mm.MethodsThin-section computed tomography (TS-CT) and FDG-PET were performed on 140 patients with resectable lung adenocarcinomas ≤30 mm between March 2006 and May 2008. Tumors were classified as air-type or solid-type based on TS-CT findings. In all resected specimens, diameter of the pathological invasive area and Ki-67 index were assessed.ResultsSUVmax was significantly lower for air-type than for solid-type tumors (0.97 vs. 3.96, p < 0.0001). In solid-type tumors, SUVmax correlated with diameter of TOM (r = 0.450, p < 0.0001), Ki-67 index (r = 0.567, p < 0.0001), and diameter of the pathological invasive area (r = 0.672, p < 0.0001). In multiple regression analysis, SUVmax correlated significantly with Ki-67 index and diameter of the pathological invasive area but not with diameter of TOM. The cut-off value of SUVmax for predicting invasive area >5 mm was determined as 2.15 by ROC analysis, with sensitivity of 88.3% and specificity of 84.6%.ConclusionsSUVmax correlated significantly with Ki-67 index and diameter of the pathological invasive area. The present results suggest the potential role of FDG-PET in predicting adenocarcinomas with invasive characteristics.
Journal: European Journal of Radiology - Volume 75, Issue 2, August 2010, Pages e62–e66