کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4228399 | 1609852 | 2007 | 6 صفحه PDF | دانلود رایگان |
PurposeFDG uptake mediated by glucose transporter type 1 (Glut-1) and tumor proliferative activity assessed by Ki-67 expression provide prognostic information in patients with non-small-cell lung cancer (NSCLC). Here, we compared the prognostic significances of FDG uptake, and of Glut-1 and Ki-67 expressions in patients with NSCLC.MethodsNSCLC patients (n = 53, F:M = 16:37, age 61.9 ± 12.1 years) who underwent curative resection after FDG-PET were enrolled. Thirty-one patients had stage I, 15 stage II, and 7 stage III disease. Patients were treated by surgery only (n = 12), surgery plus adjuvant oral chemotherapy (n = 32), or surgery plus adjuvant intravenous chemo- or radio-therapy (n = 9). Maximum standardized FDG uptake values (maxSUV), and the Glut-1 and Ki-67 expressions of resected tumors were analyzed for correlations and relations with tumor recurrence. The median follow-up duration was 15 months.ResultsThirteen (24.5%) of the 53 patients experienced recurrence during a median follow-up of 8 months and significant correlations were found between maxSUV, Glut-1, and Ki-67 expressions (r = 0.48–0.79, p < 0.001). Univariate analysis revealed that disease-free survival (DFS) was significantly correlated with maxSUV (<7 versus ≥7, p = 0.001), % Ki-67 expression (<25% versus ≥25%, p = 0.047), tumor size (<3 cm versus ≥3 cm, p = 0.027), and tumor cell differentiation (well/moderate versus poor, p = 0.011). However, multivariate Cox proportional analysis identified maxSUV as the only determinant of DFS (p = 0.005). Patients with a maxSUV of ≥7 (n = 14) had a significantly lower 1-year DFS rate (57.1%) than those with a maxSUV of <7 (n = 39, 89.7%).ConclusionFDG uptake is more valuable than Glut-1 or Ki-67 expression in terms of predicting prognosis in patients with resected NSCLC.
Journal: European Journal of Radiology - Volume 62, Issue 2, May 2007, Pages 214–219