کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4228563 1609859 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic enhanced MRI predicts chemosensitivity in breast cancer patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی رادیولوژی و تصویربرداری
پیش نمایش صفحه اول مقاله
Dynamic enhanced MRI predicts chemosensitivity in breast cancer patients
چکیده انگلیسی

BackgroundPrimary chemotherapy for breast cancer is effective as postoperative adjuvant therapy. However, one of the critical disadvantages was a treatment delay for patients with progressive disease. The present study attempts to clarify quantitative parameters on MRI which can be used to predict the sensitivity to treatment in breast cancer patients.MethodsThe subjects consisted of 26 patients with invasive ductal breast cancer who received primary chemotherapy before surgery. The mean maximum tumor dimension was 3.3 cm, and 21 cases had nodal involvements. Three cases demonstrated histological grade 3. Dynamic enhanced MRI was evaluated at three different time periods; prior to, in the midst of preoperative chemotherapy, and just before the initial operation. The signal intensity ratio (SIR) and early contrast uptake (ECU) were calculated, as well as the correlation between these dynamic data and the tumor reduction rates were analyzed retrospectively. P-values of less than 0.05 were considered to indicate statistically significant.ResultsResponders to chemotherapy had the significantly higher SIR and ECU values than non-responders (p = 0.0454 and 0.0334, respectively). ECU value significantly decreased as tumor reduction by chemotherapy (p = 0.0028). Pathological tumor dimension was significantly correlated with the tumor size estimated on presurgical MRI (p < 0.0001).ConclusionsOur current series demonstrated the significant correlation between pretreatment MRI data and tumor reduction by chemotherapy in breast cancer patients. With these results, it seems possible to define good and non-responders prior to treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Radiology - Volume 60, Issue 2, November 2006, Pages 270–274
نویسندگان
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