کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4234014 1282778 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic perfusion-CT assessment of early changes in blood brain barrier permeability of acute ischaemic stroke patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی رادیولوژی و تصویربرداری
پیش نمایش صفحه اول مقاله
Dynamic perfusion-CT assessment of early changes in blood brain barrier permeability of acute ischaemic stroke patients
چکیده انگلیسی

SummaryBackground and purposeDamage to the blood brain barrier (BBB) may lead to haemorrhagic transformation after ischaemic stroke. The purpose of this study was to evaluate the effect of patient characteristics and stroke severity on admission BBB permeability (BBBP) values measured with perfusion-CT (PCT) in acute ischaemic stroke patients.MethodsWe retrospectively identified 65 patients with proven ischaemic stroke admitted within 12 hours after symptom onset. Patients’ charts were reviewed for demographic variables and vascular risk factors. The Patlak's model was applied to calculate BBBP values from the PCT data in the infarct core, penumbra and non-ischaemic tissue in the contralateral hemisphere. Mean BBBP values and their 95% confidence intervals (CI) were calculated in the different tissue types. Effects of demographic variables and risk factors on BBBP were analyzed using a multivariate, generalized estimating equations (GEE) model.ResultsBBBP values in the infarct core (mean [95%CI]: 2.48 [2.16–2.85]) and penumbra (2.48 [2.21–2.79]) were significantly higher than in non-ischaemic tissue (2.12 [1.88–2.39]). Multivariate analysis demonstrated that collateral filling has effect on BBBP. Less elevated BBBP values were associated with more than 50% collateral filling.ConclusionsBBBP values are increased in ischaemic brain tissue on the admission PCT scan of acute ischaemic stroke patients. Less abnormally elevated BBBP values were observed in patients with more than 50% collateral filling, possibly explaining why there is a relationship between more collateral filling and a lower incidence of haemorrhagic transformation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroradiology - Volume 38, Issue 3, July 2011, Pages 161–166
نویسندگان
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