Thermochemical Ablation in an Ex-vivo Porcine Liver Model Using Acetic Acid and Sodium Hydroxide: Proof of Concept

The reaction of acetic acid and sodium hydroxide releases significant heat energy at the site of injection, and histologic changes are consistent with coagulation necrosis. Increased reagent concentration and volume were associated with larger temperature changes and larger areas of hyperthermia at gross pathology and infrared imaging.