Intramural Stress Increases Exponentially with Stent Diameter: A Stress Threshold for Neointimal Hyperplasia

Stent-induced intramural stress injury beyond a certain threshold may cause early restenosis by triggering neointimal hyperplasia. Maximum stress concentrations increase exponentially with stent deployment diameter, highlighting the importance of minimal stent overexpansion and novel stent designs that specifically address peak stress reduction.