Thrombus Formation at the Surface of Guide-Wire Models: Effects of Heparin-releasing or Heparin-exposing Surface Coatings

The static and dynamic in vitro assays, taken together, show that the 90/10 Na-hep provides a coating with an extremely low level of surface thrombogenicity. Use of a guide wire with a hydrophilic distal coating that releases and exposes sodium heparin may contribute to the safety of diagnostic and therapeutic interventional procedures.