Paclitaxel-induced Arterial Wall Toxicity and Inflammation: Tissue Uptake in Various Dose Densities in a Minipig Model

Overall coronary paclitaxel uptake is fairly independent from the baseline overall dose density and, hence, depends on immediate binding mechanisms of the arterial wall. This is supported by the fact that, regardless of the applied dose density, the kinetics of paclitaxel uptake did not follow an exposure time pattern.