کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4244582 | 1283405 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
De la physiopathologie des calcifications vasculaires aux nouveaux marqueurs biologiques chez l'insuffisant rénal chronique
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
رادیولوژی و تصویربرداری
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چکیده انگلیسی
Vascular calcifications constitute an important risk factor for mortality in chronic kidney disease patients. A better knowledge of physiopathologic phenomena responsible for vascular mineralization leads to emerging biological markers of vascular calcifications. In calcified arteries, presence of bone matrix as well as osteoblast cells suggest that vascular calcification is an active and highly regulated process. In uremic environment, vascular smooth muscle cells can transdifferentiate into osteoblast-like cells. The OPG-RANK-RANKL system is clearly of central significance in controlling vascular calcifications as in bone metabolism. Converging results suggest that circulating OPG determination should be a relevant marker of calcifications. Impairment in inhibitory system such as Matrix Gla Protein and fetuin-A promotes bone matrix calcification. Finally, FGF-23, an early and sensitive marker of bone and mineral disorders in chronic kidney disease patients, appears as a promising marker.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Médecine Nucléaire - Volume 33, Issue 1, January 2009, Pages 53-61
Journal: Médecine Nucléaire - Volume 33, Issue 1, January 2009, Pages 53-61
نویسندگان
J.-P. Cristol, A.-S. Bargnoux, A.-M. Dupuy, M. Morena, A. Avignon, B. Canaud,