کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4251411 1284019 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Therapeutic Radionuclides: Biophysical and Radiobiologic Principles
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی رادیولوژی و تصویربرداری
پیش نمایش صفحه اول مقاله
Therapeutic Radionuclides: Biophysical and Radiobiologic Principles
چکیده انگلیسی

Although the general radiobiologic principles underlying external beam therapy and radionuclide therapy are the same, there are significant differences in the biophysical and radiobiologic effects between the 2 types of radiation. In addition to the emission of particulate radiation, targeted radionuclide therapy is characterized by (1) extended exposures and, usually, declining dose rates; (2) nonuniformities in the distribution of radioactivity and, thus, absorbed dose; and (3) particles of varying ionization density and, hence, quality. This review explores the special features that distinguish the biologic effects consequent to the traversal of charged particles through mammalian cells. It also highlights what has been learned when these radionuclides and radiotargeting pharmaceuticals are used to treat cancers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Nuclear Medicine - Volume 38, Issue 5, September 2008, Pages 358–366
نویسندگان
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