کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
430942 688234 2007 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mass spectra alignments and their significance
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نظریه محاسباتی و ریاضیات
پیش نمایش صفحه اول مقاله
Mass spectra alignments and their significance
چکیده انگلیسی

Mass Spectrometry has become one of the most popular analysis techniques in Genomics and Systems Biology. We investigate a general framework that allows the alignment (or matching) of any two mass spectra. In particular, we examine the alignment of a reference mass spectrum generated in silico from a database, with a measured sample mass spectrum. In this context, we assess the significance of alignment scores for character-specific cleavage experiments, such as tryptic digestion of amino acids. We present an efficient approach to estimate this significance, with runtime linear in the number of detected peaks. In this context, we investigate the probability that a random string over a weighted alphabet contains a substring of some given weight.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Discrete Algorithms - Volume 5, Issue 4, December 2007, Pages 714–728
نویسندگان
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