کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4318819 | 1613251 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipopolysaccharide induced increase in seizure activity in two animal models of absence epilepsy WAG/Rij and GAERS rats and Long Evans rats
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کلمات کلیدی
LPSHVRSIL-1RCOX-2TLR4SWDIL-1βPGE2i.p.Electroencephalogram - الکتروانسفالوگرافیind - اندرIndomethacin - اندومتاسینinterleukin-1 β - اینترلوکین-1βSpike–wave discharges - تخلیه موج اسپایکspike–wave discharge - تخلیه موج سنبلهtumor necrosis factor-α - تومور نکروز عامل αintraperitoneal - داخل صفاقیCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیCyclooxygenase-2 - سیکلوکوکسیژناز2TNF-α - فاکتور نکروز توموری آلفاlipopolysaccharide - لیپوپلی ساکاریدWAG/Rij rats - موش های WAG / RowEEG - نوار مغزیProstaglandin E2 - پروستاگلاندین E2AMPA receptor - گیرنده AMPAinterleukin-1 receptor - گیرنده اینترلوکین-1Toll-like receptor 4 - گیرنده تله مانند 4
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lipopolysaccharide induced increase in seizure activity in two animal models of absence epilepsy WAG/Rij and GAERS rats and Long Evans rats Lipopolysaccharide induced increase in seizure activity in two animal models of absence epilepsy WAG/Rij and GAERS rats and Long Evans rats](/preview/png/4318819.png)
چکیده انگلیسی
We showed previously that the number and time of spike-wave discharges (SWDs) were increased after intraperitoneal (i.p.) injection of lipopolysaccharide (LPS), an effect, which was completely abolished by cyclooxygenase-2 (COX-2) inhibitor indomethacin (IND) pretreatment in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. These and other results suggest that injection of LPS to genetically absence epileptic animals, such as WAG/Rij rats, may allow us to investigate relationships between absence epilepsy and LPS evoked neuroinflammation processes. However, LPS may evoke different effects on absence epileptic activity in various animal strains. Thus, to extend our previous results, we injected two doses of LPS (50 μg/kg and 350 μg/kg i.p.) alone and in combination with IND (10 mg/kg IND i.p. +50 μg/kg LPS) into rats of two model animal strains (WAG/Rij rats; GAERS rats: Genetic Absence Epileptic Rats from Strasbourg) and into Long Evans rats. The effects of treatments on SWD number and SWD duration were examined. Both doses of LPS increased the SWD number and the total time of SWDs dose-dependently during the whole 4-h recording period, which was abolished by IND pretreatment in all three investigated strains. These results extend our previous results suggesting that our methods using LPS injection into freely moving absence epileptic rats is applicable not only in well-established animal models of absence epilepsy such as WAG/Rij rats and GAERS rats but also in Long Evans rats to investigate links between inflammation and absence epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 104, May 2014, Pages 7-18
Journal: Brain Research Bulletin - Volume 104, May 2014, Pages 7-18
نویسندگان
Zsolt Kovács, Árpád Dobolyi, Gábor Juhász, Katalin A. Kékesi,