کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4319093 | 1290794 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Total oligomeric flavonoids of Cyperus rotundus ameliorates neurological deficits, excitotoxicity and behavioral alterations induced by cerebral ischemic-reperfusion injury in rats
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کلمات کلیدی
Cyperus rotundusAMPAGluRDTNBNMDARNBTTBARSmGluRIAECTLCGSHTCAsulphosalicylic acidDNPHTBASSAEAATα-amino-3-hydroxyl-5-methyl-4-isoxazole-propionateMDAPMSHPTLCMCAO/RBHTMCAOONOO− - ONOO-ATP - آدنوزین تری فسفات یا ATPTrichloro acetic acid - اسید استیک تریکلروThiobarbituric acid - اسید تیوباربیتوریکMiddle cerebral artery occlusion and reperfusion - انسداد سرخرگ مغزی و رپرفیوژنmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیcornu ammonis - بال آمونNitro blue tetrazolium chloride - تترازولیم کلرید نیترو آبیexcitatory amino acid transporters - حمل کننده های اسید آمینه تحریک کنندهDinitrophenyl hydrazine - دینیتروفنیل هیدرازینSOD - سدSuperoxide - سوپر اکسیدSuperoxide dismutase - سوکسوکس دیسموتازsham-operated - شام کار می کندmalondialdehyde - مالون دی آلدهیدAnsa - مورد علاقهNAD - نادانNADH - نادانNitric oxide - نیتریک اکسیدnicotinamide adenine dinucleotide reduced - نیکوتین آمید adenine dinucleotide کاهش می یابدNAD, nicotinamide adenine dinucleotide - نیکوتینامید آدنین دینوکلئوتیدbutylated hydroxyl toluene - هیدروکسیل تولوئل بوتیل شدهreduced glutathione - کاهش گلوتاتیونthin layer chromatography - کروماتوگرافی لایه نازکhigh performance thin layer chromatography - کروماتوگرافی نازک با عملکرد بالاInstitutional Animal Ethical Committee - کمیته اخلاقی حیوانات نهادGlutamine synthetase - گلوتامین سنتتازN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartateMetabotropic glutamate receptor - گیرنده گلوتامات متابوتروپیکGlutamate receptor - گیرنده گلومات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Total oligomeric flavonoids of Cyperus rotundus ameliorates neurological deficits, excitotoxicity and behavioral alterations induced by cerebral ischemic-reperfusion injury in rats Total oligomeric flavonoids of Cyperus rotundus ameliorates neurological deficits, excitotoxicity and behavioral alterations induced by cerebral ischemic-reperfusion injury in rats](/preview/png/4319093.png)
چکیده انگلیسی
Interactions between neurons and astrocytes play a critical role in the central nervous system homeostasis. Cyperus rotundus (family: Cyperaceae), a traditional Indian medicinal herb, used as nervine tonic and nootropic in the Ayurvedic system of medicine. The present study was undertaken to investigate the neuroprotective effect of total oligomeric flavonoids (TOFs), prepared from C. rotundus, in rat model of cerebral ischemia and reperfusion. Male Sprague Dawley rats (290-340 g) were subjected to middle cerebral artery occlusion (MCAO) for 2 h and reperfusion for 70 h. Experimental animals were divided into four groups: Group I - sham operated (n = 7); Group II - vehicle treated ischemic-reperfusion (IR) (n = 9), and Group III and IV - TOFs treated (100 and 200 mg/kg body weight, p.o., respectively; n = 7 in each group). Vehicle or TOFs were pretreated for four days before the induction of ischemia and continued for next three days after the ischemia i.e. treatment was scheduled totally for a period of 7 days. MCAO surgery was performed on day 4, 1 h after TOFs administration. Neuroprotective effect of TOFs was substantiated in terms of neurological deficits, excitotoxicity (glutamate, glutamine synthetase and Na+K+ATPase levels), oxidative stress (malondialdehyde, super oxide dismutase, and glutathione) and neurobehavioral functions in the experimental animals. TOFs decreased glutamate, glutamine synthetase (GS) and increased Na+K+ATPase activity in a dose dependent manner when compared to the IR rats. Treatment with TOFs significantly reduced the neurological deficits and reversed the anxiogenic behavior in rats. Further, it also significantly decreased MDA and increased superoxide dismutase (SOD) and glutathione content in brains of experimental rats. Histopathological examination using cresyl violet staining revealed the attenuation of neuronal loss by TOFs in stroke rats. The present study demonstrates the unswerving involvement of TOFs on ischemia-reperfusion triggered biochemical alterations in MCAO/R rats. Hence, TOFs might be an attractive candidate for further studies in the development of new drugs for cerebral stroke treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 84, Issue 6, 5 April 2011, Pages 394-405
Journal: Brain Research Bulletin - Volume 84, Issue 6, 5 April 2011, Pages 394-405
نویسندگان
A.G. Sunil, K.S. Kesavanarayanan, P. Kalaivani, S. Sathiya, V. Ranju, R. Jyothi Priya, B. Pramila, F.D. Solomon Paul, J. Venkhatesh, C. Saravana Babu,