Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice

► Our aim was to gain insight into the mechanism of hyperphagia of BDNF KO mice. ► Feeding behavior and vagal afferent innervation of BDNF KO mice were characterized. ► Meal size and number were increased, suggesting deficits in satiation and satiety. ► Increased vagal motor activation by a meal suggested accommodation reflex was augmented. ► Augmented accommodation reflex may contribute to reduced satiation and satiety.