کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341682 | 1295843 | 2006 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Developmental changes in presynaptic muscarinic modulation of excitatory and inhibitory neurotransmission in rat piriform cortex in vitro: Relevance to epileptiform bursting susceptibility
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
OXO-MNMDARα-amino-3-hydroxy-5-methylisoxazole-4-propionic aciddl-2-amino-5-phosphonovaleric acidGABA type A receptorN-methyl-d-aspartateNMDALIADL-APVAMPAOxotremorine-MmAChRPDSDPSPPPFLiBdepolarizing postsynaptic potential6-cyano-7-nitro-quinoxaline-2,3-dione - 6-سینو-7-نیترو کینوکسالین-2،3-دیونDMSO - DMSOEPSP - epspiISI - آی اس آیpaired-pulse facilitation - تسکین زوایای پالسیParoxysmal depolarizing shift - تغییر دلفریزی پاروکسیسمالdimethylsulphoxide - دی متیل سولفوکسیدDevelopment - رشدCNQX - سیانکیوایکسInterstimulus interval - فاصله بین فاصلهpiriform cortex - قشر پریکومlateral olfactory tract - قطعه بویایی جانبیLot - لوطexcitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیزGABAAR - گابارGABABR - گابربN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartatemuscarinic acetylcholine receptor - گیرنده استیل کولین muscarinic
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Developmental changes in presynaptic muscarinic modulation of excitatory and inhibitory neurotransmission in rat piriform cortex in vitro: Relevance to epileptiform bursting susceptibility Developmental changes in presynaptic muscarinic modulation of excitatory and inhibitory neurotransmission in rat piriform cortex in vitro: Relevance to epileptiform bursting susceptibility](/preview/png/4341682.png)
چکیده انگلیسی
Suppression of depolarizing postsynaptic potentials and isolated GABA-A receptor-mediated fast inhibitory postsynaptic potentials by the muscarinic acetylcholine receptor agonist, oxotremorine-M (10 μM), was investigated in adult and immature (P14-P30) rat piriform cortical (PC) slices using intracellular recording. Depolarizing postsynaptic potentials evoked by layers II-III stimulation underwent concentration-dependent inhibition in oxotremorine-M that was most likely presynaptic and M2 muscarinic acetylcholine receptor-mediated in immature, but M1-mediated in adult (P40-P80) slices; percentage inhibition was smaller in immature than in adult piriform cortex. In contrast, compared with adults, layer Ia-evoked depolarizing postsynaptic potentials in immature piriform cortex slices in oxotremorine-M, showed a prolonged multiphasic depolarization with superimposed fast transients and spikes, and an increased 'all-or-nothing' character. Isolated N-methyl-d-aspartate receptor-mediated layer Ia depolarizing postsynaptic potentials (although significantly larger in immature slices) were however, unaffected by oxotremorine-M, but blocked by dl-2-amino-5-phosphonovaleric acid. Fast inhibitory postsynaptic potentials evoked by layer Ib or layers II-III-fiber stimulation in immature slices were significantly smaller than in adults, despite similar estimated mean reversal potentials (â¼â69 and â70 mV respectively). In oxotremorine-M, only layer Ib-fast inhibitory postsynaptic potentials were suppressed; suppression was again most likely presynaptic M2-mediated in immature slices, but M1-mediated in adults. The degree of fast inhibitory postsynaptic potential suppression was however, greater in immature than in adult piriform cortex. Our results demonstrate some important physiological and pharmacological differences between excitatory and inhibitory synaptic systems in adult and immature piriform cortex that could contribute toward the increased susceptibility of this region to muscarinic agonist-induced epileptiform activity in immature brain slices.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 140, Issue 3, 2006, Pages 939-956
Journal: Neuroscience - Volume 140, Issue 3, 2006, Pages 939-956
نویسندگان
B.J. Whalley, A. Constanti,