کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4343651 | 1615121 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Plasma glucocorticoids differentially modulate phasic and tonic GABA inhibition during early postnatal development in rat spinal lamina II
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کلمات کلیدی
FISBICLEWSHRPBicucullineIPSCRIAaCSFSprague-Dawley - اسپراگ داولیγ-aminobutyric acid - اسید γ-آمینوبوتیریکinhibitory postsynaptic current - جریان پستانیپتیک مهارکنندهMechanical pain sensitivity - حساسیت درد مکانیکیstress hyporesponsive period - دوره تنش هیپوروسپنجیradioimmunoassay - رادیوایمونواسیSpinal dorsal horn - شاخ پشتی نخاعیFischer - فیشرFinasteride - فیناسترایدLewis - لوئیسartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیHypothalamic-pituitary-adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالHPA - میلی بار یا هکتوپاسکالfin - پایانCORT - کورتCorticosterone - کورتیکوسترونGABA - گاباGABAAR - گابارGabazine - گابازینGlucocorticoids - گلوکوکورتیکوئیدهاGABAA receptor - گیرنده GABAA یا گیرنده گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Nociceptive processing is tuned by GABAA receptor-mediated inhibition in the spinal cord dorsal horn that undergoes postnatal maturation in rodents. These GABAergic inhibitory postsynaptic currents (IPSCs) are modulated by 3α5α-reduced steroids during early postnatal development in spinal cord lamina II. Thus an enhanced phasic inhibition is present in neonates and decreases over time. GABA can also activate extrasynaptic receptors, giving rise to tonic inhibition. In this study, we characterized the contribution of plasma corticosterone (CORT) to postnatal maturation of spinal phasic and, for the first time, tonic GABAergic inhibitions. We used Fisher and Lewis rat strains displaying respectively high and low hypothalamic-pituitary-adrenal axis reactivity, compared to control Sprague-Dawley rats. Measured plasma CORT levels were significantly higher in Fisher rats, which also displayed significantly higher mechanical nociceptive thresholds, supporting the hypothesis of an antinociceptive action of CORT. Recorded GABAA IPSCs shortened during maturation in all strains while remaining larger in Fisher rats. Blocking the 5α-reduction of steroids in Fisher rats produced a further decrease of IPSC deactivation time constant. In contrast, GABAA tonic inhibition progressively increased during maturation, without any difference among strains. In conclusion, we show that both phasic and tonic GABAergic inhibitions undergo postnatal maturation in lamina II. Moreover spinal production of 3α5α-reduced steroids that presumably derive from plasma CORT is correlated to spinal GABAA phasic (but not tonic) inhibition and to mechanical nociceptive thresholds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 578, 22 August 2014, Pages 39-43
Journal: Neuroscience Letters - Volume 578, 22 August 2014, Pages 39-43
نویسندگان
Vivien Zell, Ulrike Hanesch, Pierrick Poisbeau, Fernand Anton, Pascal Darbon,