Chronic stress impairs learning and hippocampal cell proliferation in senescence-accelerated prone mice

▶ SAMP8 is more sensitive to the negative effects of CRS on learning than SAMR1. ▶ CRS induces a greater decrease in hippocampal cell proliferation in SAMP8 than SAMR1. ▶ CRS decreases BDNF expression in the hippocampus in both SAMR1 and SAMP8.