کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4347005 1296815 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age-related changes in antioxidant enzymes related to hydrogen peroxide metabolism in rat inner ear
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Age-related changes in antioxidant enzymes related to hydrogen peroxide metabolism in rat inner ear
چکیده انگلیسی

Oxidative stress is a pervasive factor in aging and has been implicated in noise-induced cochlear pathology. In this study, we measured the activities of two enzymes that catalyze the removal of hydrogen peroxide (H2O2), catalase and glutathione peroxidase (Gpx), in 3- and 24-month-old Fisher-344 rats, and reduced and oxidized glutathione in 3-, 12-, and 24-month-old rats. There was an increase in Gpx activity in vascular tissue (spiral ligament and stria vascularis), but no change in modiolar, sensory or vestibular tissue of the cochlea. The elevation in vascular tissue was age-related. We observed a significant elevation of catalase activity in vestibular tissue, a tendency for age-related elevation in the modiolus, but no change in vascular or sensory cochlear tissue. These findings suggest that increased Gpx activity in vascular cochlear tissue may be an age-related compensation for a decrease in glutathione and a decline in the redox state measured by the ratio of reduced to oxidized glutathione.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 464, Issue 1, 16 October 2009, Pages 22–25
نویسندگان
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