کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4349137 | 1296926 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An association study between the genetic polymorphisms within TBX1 and schizophrenia in the Chinese population
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: An association study between the genetic polymorphisms within TBX1 and schizophrenia in the Chinese population An association study between the genetic polymorphisms within TBX1 and schizophrenia in the Chinese population](/preview/png/4349137.png)
چکیده انگلیسی
The strong association between common psychiatric disorders and the 22q11.2 microdeletion suggests that haploinsufficiency of one or more genes in the region confers susceptibility to these disorders. Recent mouse studies have shown that the T-box 1 (TBX1) gene in the 22q11.2 region can cause prepulse inhibition (PPI) impairment in the heterozygous state. A study has also shown that phenotypic features of 22q11 deletion syndrome (22q11DS) were segregated with an inactivating mutation of TBX1 in one family, suggesting that the TBX1 gene plays a role in the pathogenesis of some psychiatric disorders. We performed an association study between three single nucleotide polymorphisms (SNPs) in the TBX1 gene and schizophrenia. However, we found no significant difference in the genotype or allele distributions between the 328 schizophrenics and 288 controls for any of the polymorphisms, nor was there any haplotype association. Our data suggest that the genetic polymorphisms within TBX1 do not confer an increased susceptibility to schizophrenia in the Chinese population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 425, Issue 3, 2 October 2007, Pages 146-150
Journal: Neuroscience Letters - Volume 425, Issue 3, 2 October 2007, Pages 146-150
نویسندگان
Gang Ma, YongYong Shi, Wei Tang, ZangDong He, Ke Huang, ZhiQiang Li, Guang He, GuoYin Feng, HuaFang Li, Lin He,