کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4356058 | 1615657 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss
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کلمات کلیدی
SGNNT-3SNHLABRSPLeABR - EABRElectrical stimulation - تحریک الکتریکیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancestandard error of mean - خطای استاندارد میانگینIntravenous - داخل وریدیdecibel - دسیبلsubcutaneous - زیر جلدیIntramuscular - عضلانیInternal Diameter - قطر داخلیSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیdeafness - ناشنواییneural degeneration - ناهنجاری عصبیNeurotrophin - نوروتروفینNeurotrophin 3 - نوروتروفین 3spiral ganglion neuron - نورون گانگلیون مارپیچیauditory brainstem response - پاسخ شنوایی مغزElectrically-evoked auditory brainstem response - پاسخ مغزی شنوایی شنوایی الکتریکیPascal - پاسکالNeural prostheses - پروتز عصبیPlatinum - پلاتینCochlear implant - کاشت حلزونیsensorineural hearing loss - کم شنوایی حسی عصبی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Exogenous neurotrophins (NTs) have been shown to rescue spiral ganglion neurons (SGNs) from degeneration following a sensorineural hearing loss (SNHL). Furthermore, chronic electrical stimulation (ES) has been shown to retard SGN degeneration in some studies but not others. Since there is evidence of even greater SGN rescue when NT administration is combined with ES, we examined whether chronic ES can maintain SGN survival long after cessation of NT delivery. Young adult guinea pigs were profoundly deafened using ototoxic drugs; five days later they were unilaterally implanted with an electrode array and drug delivery system. Brain derived neurotrophic factor (BDNF) was continuously delivered to the scala tympani over a four week period while the animal simultaneously received ES via bipolar electrodes in the basal turn (i.e., turn 1) scala tympani. One cohort (n = 5) received ES for six weeks (i.e., including a two week period after the cessation of BDNF delivery; ES6); a second cohort (n = 5) received ES for 10 weeks (i.e., a six week period following cessation of BDNF delivery; ES10). The cochleae were harvested for histology and SGN density determined for each cochlear turn for comparison with normal hearing controls (n = 4). The withdrawal of BDNF resulted in a rapid loss of SGNs in turns 2-4 of the deafened/BDNF-treated cochleae; this was significant as early as two weeks following removal of the NT when compared with normal controls (p < 0.05). Importantly, there was not a significant reduction in SGNs in turn 1 (i.e., adjacent to the electrode array) two and six weeks after NT removal, as compared with normal controls. This result suggests that chronic ES can prevent the rapid loss of SGNs that occurs after the withdrawal of exogenous NTs. Implications for the clinical delivery of NTs are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 242, Issues 1â2, August 2008, Pages 100-109
Journal: Hearing Research - Volume 242, Issues 1â2, August 2008, Pages 100-109
نویسندگان
Robert K. Shepherd, Anne Coco, Stephanie B. Epp,