کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4359964 1301128 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The immunomodulating role of exercise in metabolic disease
ترجمه فارسی عنوان
نقش ایمن سازی در ورزش در بیماری متابولیک
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


• Lipid accumulation is linked to inflammation in a setting of nutrient overload.
• Exercise training reduces levels of proinflammatory cytokines in adipose tissue.
• Exercise may reduce inflammation by decreasing lipid accretion in liver and muscle.
• Anti-inflammatory effects may be mediated via inhibition of TLR and IL-1 signaling.

A lack of physical activity is linked to the development of many chronic diseases. It is now well established that the immune system and inflammation play a central role in the development of numerous chronic metabolic diseases including insulin resistance, type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and specific types of cancer. Physical exercise elicits potent anti-inflammatory effects that are likely to account for many of the salutary actions of regular exercise on chronic metabolic diseases. Here we review the anti-inflammatory and immunomodulatory mechanisms by which the beneficial effects of exercise on chronic metabolic diseases may be mediated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 35, Issue 6, June 2014, Pages 262–269
نویسندگان
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