کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4360101 1301143 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High-mobility group box family of proteins: ligand and sensor for innate immunity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
High-mobility group box family of proteins: ligand and sensor for innate immunity
چکیده انگلیسی

Recent discoveries in signal-transducing innate receptors have illustrated the close link between innate and adaptive immunity. These advances revisit a fundamental issue of immunology, the recognition of self and non-self molecules by the immune system. Indeed, mounting evidence has been provided that the sensing of self-derived molecules by the immune system is important for health and disease. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived immune activators that have multiple functions in the regulation of immunity and inflammation. In this review, we summarize current knowledge of the function of HMGB proteins, as a ligand that can evoke inflammatory responses, and as a sensor for nucleic-acid-mediated immune responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 33, Issue 12, December 2012, Pages 633–640
نویسندگان
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