کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4360425 1301182 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Do adaptive immune cells suppress or activate innate immunity?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Do adaptive immune cells suppress or activate innate immunity?
چکیده انگلیسی

Current dogma holds that the innate immune system primes the adaptive immune system in response to infection, which in turn amplifies innate responses in a positive loop to effectively control pathogens. Therefore, it is accepted in most cases that T-cell deficient hosts die of acute infection because of the impaired ability of the innate immune system to control pathogens. Recent studies, however, reveal that adaptive immune cells actively dampen initial innate responses. In contrast to current understanding, there is now evidence that an insufficient number of T cells results in loss of control of innate immune responses. This raises new questions regarding the, as of yet underappreciated, role of the adaptive immune system in early infection and inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 30, Issue 1, January 2009, Pages 8–12
نویسندگان
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