Influenza Virus-Induced Glucocorticoids Compromise Innate Host Defense against a Secondary Bacterial Infection

SummaryMulticellular organisms are continuously exposed to many different pathogens. Because different classes of pathogens require different types of immune responses, understanding how an ongoing immune response to one type of infection affects the host's ability to respond to another pathogen is essential for a complete understanding of host-pathogen interactions. Here, we used a mouse model of coinfection to gain insight into the effect of respiratory influenza virus infection on a subsequent systemic bacterial infection. We found that influenza infection triggered a generalized stress response leading to a sustained increase in serum glucocorticoid levels, resulting in a systemic suppression of immune responses. However, virus-induced glucocorticoid production was necessary to control the inflammatory response and prevent lethal immunopathology during coinfection. This study demonstrates that activation of the hypothalamic-pituitary-adrenal axis controls the balance between immune defense and immunopathology and is an important component of the host response to coinfection.

Graphical AbstractFigure optionsDownload high-quality image (428 K)Download as PowerPoint slideHighlights
► Influenza virus increases the burden of a coinfecting systemic bacterial pathogen
► Influenza virus suppresses systemic immune responses via glucocorticoid (GC) induction
► GC removal rescues immunosuppression but enhances inflammatory response to coinfection
► GCs control balance of immune defense and immune pathology during influenza infection