کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4407780 1618820 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aluminum chloride induces neuroinflammation, loss of neuronal dendritic spine and cognition impairment in developing rat
ترجمه فارسی عنوان
کلرید آلومینیوم باعث التهاب عصبی، از بین رفتن ستون فقرات دندریتیک عصبی و اختلال شناخت در رشد موش صحرایی
کلمات کلیدی
کلرید آلومینیوم، عصب خونی ستون دندریتیک، اختلال شناختی، هیپوکامپ، موش
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


• AlCl3 caused neuroinflammation in hippocampus.
• AlCl3 caused loss of dendritic spine in hippocampus.
• Loss of spine may result in cognition impairment of AlCl3-treated rats.

Aluminum (Al) is present in the daily life of humans, and the incidence of Al contamination increased in recent years. Long-term excessive Al intake induces neuroinflammation and cognition impairment. Neuroinflammation alter density of dendritic spine, which, in turn, influence cognition function. However, it is unknown whether increased neuroinflammation is associated with altered density of dendritic spine in Al-treated rats. In the present study, AlCl3 was orally administrated to rat at 50, 150 and 450 mg/kg for 90d. We examined the effects of AlCl3 on the cognition function, density of dendritic spine in hippocampus of CA1 and DG region and the mRNA levels of IL-1β, IL-6, TNF-α, MHC II, CX3CL1 and BNDF in developing rat. These results showed exposure to AlCl3 lead to increased mRNA levels of IL-1β, IL-6, TNF-α and MCH II, decreased mRNA levels of CX3CL1 and BDNF, decreased density of dendritic spine and impaired learning and memory in developing rat. Our results suggest AlCl3 can induce neuroinflammation that may result in loss of spine, and thereby leads to learning and memory deficits.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 151, May 2016, Pages 289–295
نویسندگان
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