کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4408474 1618843 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tamoxifen ecotoxicity and resulting risks for aquatic ecosystems
ترجمه فارسی عنوان
سم زدایی تاموکسیفن و خطرات ناشی از آن برای اکوسیستم های آبزی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


• First ecotoxicity tests of tamoxifen on algae.
• A PNEC of tamoxifen for continental aquatic ecosystems of 81 ng L−1.
• Risk quotients of tamoxifen calculate for four situations.
• Tamoxifen could present a significant environmental risk for aquatic ecosystems.

Tamoxifen, a drug used to treat cancer, is regularly found in hydrosystems at concentrations of several hundred ng L−1. To characterize its ecotoxicity, we implemented a battery of bioassays on organisms belonging to 3 different trophic levels: Pseudokirchneriella subcapitata, Chlorella vulgaris and Chlamydomonas reinhardtii, for primary producers, Daphnia magna (immobilization, grazing and reproduction) for primary consumers, and Danio rerio for secondary consumers (embryotoxicity test). In view of the results obtained and the ecotoxicity values of tamoxifen available in the literature, we established a PNEC (Predictive No Effect Concentration) equal to 81 ng L−1 for continental water. This PNEC allowed us to calculate Risk Quotients (RQ) for 4 continental hydrosystems in 4 different countries in which measures of tamoxifen had already been performed on surface waters. In two of the situations studied, RQs were higher than 1, reaching a maximum of 2.6. These results show the need to deepen the characterization of ecotoxicological risks linked to the discharge of tamoxifen in surface waters. In addition, we propose applying this approach to other drug residues detected in the environment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 128, June 2015, Pages 79–84
نویسندگان
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