کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4421032 | 1308502 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Repeated malathion exposure induces behavioral impairment and AChE activity inhibition in brains of rat pups Repeated malathion exposure induces behavioral impairment and AChE activity inhibition in brains of rat pups](/preview/png/4421032.png)
The present study evaluated if repeated malathion administration would cause behavioral impairment in rat pups. Na+ K+ ATPase and acetylcholinesterase (AChE) activities were investigated in brains of rat pups. Malathion was administered (100 or 200 mg/kg) orally (p.o.), once a day for four consecutive days. Rat pups were submitted to behavioral tests on the 5th day, 24 h after the last malathion administration. Malathion at the dose of 200 mg/kg caused a significant increase in the negative geotaxis latency and a decrease in the rotarod latency of rat pups. Rat pups exposed to malathion at both doses showed a significant decrease in the forelimb support latency and an inhibition of brain AChE activity. Repeated exposure of rat pups to malathion caused a decrease in motor coordination, vestibular function and muscular strength/coordination. The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups.
► Malathion increased the negative geotaxis latency and decreased the rotarod latency of pups.
► Malathion decreased motor coordination, vestibular function and muscular coordination.
► The brain activity of AChE is involved in the behavioral alterations caused by malathion in rat pups.
Journal: Ecotoxicology and Environmental Safety - Volume 74, Issue 8, November 2011, Pages 2310–2315