کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4499971 1624019 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toxin effect on protein biosynthesis in eukaryotic cells: A simple kinetic model
ترجمه فارسی عنوان
اثر توکسین بر بیوسنتز پروتئین در سلول های یوکاریوتی: یک مدل سینتیک ساده
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Model for toxin inhibition of protein synthesis in eukaryotic cells is proposed.
• Mitigation of toxin inhibition for protein synthesis by antibodies is studied.
• Toxin dosage influence on antibody protection measure is studied.

A model for toxin inhibition of protein synthesis inside eukaryotic cells is presented. Mitigation of this effect by introduction of an antibody is also studied. Antibody and toxin (ricin) initially are delivered outside the cell. The model describes toxin internalization from the extracellular into the intracellular domain, its transport to the endoplasmic reticulum (ER) and the cleavage inside the ER into the RTA and RTB chains, the release of RTA into the cytosol, inactivation (depurination) of ribosomes, and the effect on translation. The model consists of a set of ODEs which are solved numerically. Numerical results are illustrated by figures and discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 261, March 2015, Pages 83–90
نویسندگان
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