Toxin effect on protein biosynthesis in eukaryotic cells: A simple kinetic model

• Model for toxin inhibition of protein synthesis in eukaryotic cells is proposed.
• Mitigation of toxin inhibition for protein synthesis by antibodies is studied.
• Toxin dosage influence on antibody protection measure is studied.

A model for toxin inhibition of protein synthesis inside eukaryotic cells is presented. Mitigation of this effect by introduction of an antibody is also studied. Antibody and toxin (ricin) initially are delivered outside the cell. The model describes toxin internalization from the extracellular into the intracellular domain, its transport to the endoplasmic reticulum (ER) and the cleavage inside the ER into the RTA and RTB chains, the release of RTA into the cytosol, inactivation (depurination) of ribosomes, and the effect on translation. The model consists of a set of ODEs which are solved numerically. Numerical results are illustrated by figures and discussed.