کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4500300 | 1319978 | 2012 | 8 صفحه PDF | دانلود رایگان |
Recent experiments indicate that one of the likely reasons of the failure of eradication of HIV is in infection of hematopoietic progenitor cells. Such cells are nurtured in stem-cell niches residing in the bone marrow. Our generic four-variable kinetic model focused on this ingredient of HIV infection describes (i) a rapid increase of the population of infected CD4+ T cells at the beginning of verimia, (ii) a sharp decline of this population due to immunological control, (iii) a long period of latency followed by a collapse of the immune system, and (iv) predicts that in the case of the therapy fully eradicating infected CD4+ T cells the infection starts rapidly again after the therapy.
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► One of the likely reasons of the failure of eradication of HIV is in infection of hematopoietic progenitor cells.
► Such cells are nurtured in stem-cell niches residing in the bone marrow.
► Our generic four-variable kinetic model is focused on this ingredient of HIV infection.
► It describes the beginning of verimia and a long period of latency followed by a collapse of the immune system.
Journal: Mathematical Biosciences - Volume 236, Issue 1, March 2012, Pages 36–43