کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4502730 | 1320596 | 2008 | 23 صفحه PDF | دانلود رایگان |
We use traveling-wave theory to derive expressions for the rate of accumulation of deleterious mutations under Muller's ratchet and the speed of adaptation under positive selection in asexual populations. Traveling-wave theory is a semi-deterministic description of an evolving population, where the bulk of the population is modeled using deterministic equations, but the class of the highest-fitness genotypes, whose evolution over time determines loss or gain of fitness in the population, is given proper stochastic treatment. We derive improved methods to model the highest-fitness class (the stochastic edge) for both Muller's ratchet and adaptive evolution, and calculate analytic correction terms that compensate for inaccuracies which arise when treating discrete fitness classes as a continuum. We show that traveling-wave theory makes excellent predictions for the rate of mutation accumulation in the case of Muller's ratchet, and makes good predictions for the speed of adaptation in a very broad parameter range. We predict the adaptation rate to grow logarithmically in the population size until the population size is extremely large.
Journal: Theoretical Population Biology - Volume 73, Issue 1, February 2008, Pages 24–46