کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4502805 | 1320601 | 2007 | 12 صفحه PDF | دانلود رایگان |
The squared correlation coefficient r2r2 (sometimes denoted Δ2Δ2) is a measure of linkage disequilibrium that is widely used, but computing its expectation E[r2]E[r2] in the population has remained an intriguing open problem. The expectation E[r2]E[r2] is often approximated by the standard linkage deviation σd2, which is a ratio of two expectations amenable to analytic computation. In this paper, a method of computing the population-wide E[r2]E[r2] is introduced for a model with recurrent mutation, genetic drift and recombination. The approach is algebraic and is based on the diffusion process approximation. In the limit as the population-scaled recombination rate ρρ approaches ∞∞, it is shown rigorously that the asymptotic behavior of E[r2]E[r2] is given by 1/ρ+O(ρ-2)1/ρ+O(ρ-2), which, incidentally, is the same as that of σd2. A computer software that computes E[r2]E[r2] numerically is available upon request.
Journal: Theoretical Population Biology - Volume 71, Issue 1, February 2007, Pages 49–60