کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4513572 | 1624862 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Comparative studies on Turkish and Indian Centella asiatica (L.) Urban (gotu kola) samples for their enzyme inhibitory and antioxidant effects and phytochemical characterization Comparative studies on Turkish and Indian Centella asiatica (L.) Urban (gotu kola) samples for their enzyme inhibitory and antioxidant effects and phytochemical characterization](/preview/png/4513572.png)
• Enzyme inhibitory and antioxidant activity of Centella asiatica was investigated.
• The extracts showed notable inhibition against butyrylcholinesterase and tyrosinase.
• Phenolic acids of the extracts from Turkey and India were identified by HPLC.
• Essential oil composition of the plant from Turkey was established.
• This is the first study on Centella asiatica cultivated in Turkey
In this study, enzyme inhibitory and antioxidant activity of the ethanol extracts of Centella asiatica (L.) Urban from Turkey and India was examined and the results were compared to those of the standardized extract of the plant obtained from China. Inhibitory activity of these three extracts was screened against four enzymes; acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase (TYRO), and lipoxygenase (LOX) using ELISA microplate reader. Antioxidant activity of the extracts was determined in vitro using 2,2-diphenyl-1-picrylhydrazyl (DPPH), metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. The extracts showed a notable inhibition against BChE and TYRO, while the extracts from Turkey and India displayed lower activity in the antioxidant assays. HPLC analysis indicated that the Turkish plant sample was found to be richest in p-hydroxy-benzoic acid, whilst the Indian sample contained chlorogenic acid in the most abundant amount. α-Copaene was the dominant compound in the essential oil of the plant sample from Turkey.
Journal: Industrial Crops and Products - Volume 47, May 2013, Pages 316–322