کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4753504 | 1416981 | 2017 | 5 صفحه PDF | دانلود رایگان |
- The whole genome of Streptomyces albolongus YIM 101047 was sequenced.
- This strain produces novel bafilomycins and odoriferous sesquiterpenoids.
- The genome contains forty-six putative secondary metabolite gene clusters.
Streptomyces albolongus YIM 101047 produces novel bafilomycins and odoriferous sesquiterpenoids with cytotoxic and antimicrobial activities. Here, we report the complete genome sequence of S. albolongus YIM 101047, which consists of an 8,027,788Â bp linear chromosome. Forty-six putative biosynthetic gene clusters of secondary metabolites were found. The sesquiterpenoid gene cluster was on the left arm (0.09-0.10Â Mb), and the bafilomycin biosynthetic gene cluster was on the right arm (7.46-7.64Â Mb) of the chromosome. Twenty-two putative gene clusters with high or moderate similarity to important antibiotic biosynthetic gene clusters were found, including the antitumor agents bafilomycin, epothilone and hedamycin; the antibacterial/antifungal agents clavulanic acid, collismycin A, frontalamides, kanamycin, streptomycin and streptothricin; the protein phosphatase inhibitor RK-682; and the acute iron poisoning medication desferrioxamine B. The genome sequence reported here will enable us to study the biosynthetic mechanism of these important antibiotics and will facilitate the discovery of novel secondary metabolites with potential applications to human health.
Journal: Journal of Biotechnology - Volume 262, 20 November 2017, Pages 89-93