کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4753504 1416981 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short Genome CommunicationsThe complete genome sequence of Streptomyces albolongus YIM 101047, the producer of novel bafilomycins and odoriferous sesquiterpenoids
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Short Genome CommunicationsThe complete genome sequence of Streptomyces albolongus YIM 101047, the producer of novel bafilomycins and odoriferous sesquiterpenoids
چکیده انگلیسی


- The whole genome of Streptomyces albolongus YIM 101047 was sequenced.
- This strain produces novel bafilomycins and odoriferous sesquiterpenoids.
- The genome contains forty-six putative secondary metabolite gene clusters.

Streptomyces albolongus YIM 101047 produces novel bafilomycins and odoriferous sesquiterpenoids with cytotoxic and antimicrobial activities. Here, we report the complete genome sequence of S. albolongus YIM 101047, which consists of an 8,027,788 bp linear chromosome. Forty-six putative biosynthetic gene clusters of secondary metabolites were found. The sesquiterpenoid gene cluster was on the left arm (0.09-0.10 Mb), and the bafilomycin biosynthetic gene cluster was on the right arm (7.46-7.64 Mb) of the chromosome. Twenty-two putative gene clusters with high or moderate similarity to important antibiotic biosynthetic gene clusters were found, including the antitumor agents bafilomycin, epothilone and hedamycin; the antibacterial/antifungal agents clavulanic acid, collismycin A, frontalamides, kanamycin, streptomycin and streptothricin; the protein phosphatase inhibitor RK-682; and the acute iron poisoning medication desferrioxamine B. The genome sequence reported here will enable us to study the biosynthetic mechanism of these important antibiotics and will facilitate the discovery of novel secondary metabolites with potential applications to human health.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biotechnology - Volume 262, 20 November 2017, Pages 89-93
نویسندگان
, , , , , , ,