Complete genome sequence of Lactobacillus plantarum LZ206, a potential probiotic strain with antimicrobial activity against food-borne pathogenic microorganisms

• L. plantarum LZ206 has strong antimicrobial activity against food-borne pathogens.
• We present the complete genome sequence of L. plantarum LZ206.
• The genome contains a 3,212,951-bp chromosome and three plasmids.
• A plantaricin gene cluster involving in bacteriocins biosynthesis was identified.
• LZ206 could protect food products from pathogens contamination in food industry.

Lactobacilli strains have been considered as important candidates for manufacturing “natural food”, due to their antimicrobial properties and generally regarded as safe (GRAS) status. Lactobacillus plantarum LZ206 is a potential probiotic strain isolated from raw cow milk, with antimicrobial activity against various pathogens, including Gram-positive bacteria (Staphylococcus aureus and Listeria monocytogenes), Gram-negtive bacteria (Escherichia coli and Salmonella enterica), and fungus Candida albicans. To better understand molecular base for its antimicrobial activity, entire genome of LZ206 was sequenced. It was revealed that genome of LZ206 contained a circular 3,212,951-bp chromosome, two circular plasmids and one predicted linear plasmid. A plantaricin gene cluster, which is responsible for bacteriocins biosynthesis and could be associated with its broad-spectrum antimicrobial activity, was identified based on comparative genomic analysis. Whole genome sequencing of L. plantarum LZ206 might facilitate its applications to protect food products from pathogens’ contamination in the dairy industry.