کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4766863 | 1424114 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gramicidin A ion channel formation in model phospholipid bilayers tethered to gold (111) electrode surfaces
ترجمه فارسی عنوان
گرمیسییدین تشکیل یک کانال یون در دو لایه فسفولیپید مدل که به سطوح الکترود طلا (111) وصل می شود
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
Electrochemical and polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) techniques were employed to study the ion channel properties of gramicidin A (gA) in tethered bilayer lipid membranes (tBLMs) with varying concentrations of gA added to the outer leaflet of the bilayer. The electrochemical impedance spectroscopy (EIS) results demonstrate that gA forms conductive ion channels in tBLM systems even at concentrations as low as 0.5 mol%. The impedance of the membrane depended on the gA concentration where a minimum was observed at 10 mol%. When the amount of gA in the bilayer is increased to a concentration above 10%, the ion channels appear to arrange into a non-conducting state. PM-IRRAS spectra suggest that the gA molecules adopt a tilt angle of â¼29 ± 4° in the conductive ion channel state. In the non-conducting state, the average tilt angle of the gA molecules is â¼52 ± 3°, which implies that gA peptides assume a random orientation in the tBLM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 243, 20 July 2017, Pages 364-373
Journal: Electrochimica Acta - Volume 243, 20 July 2017, Pages 364-373
نویسندگان
Zhangfei Su, J. Jay Leitch, Robert J. Faragher, Adrian L. Schwan, Jacek Lipkowski,