کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4768107 | 1424525 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination and correlation of solubility of linezolid form II in different pure and binary solvents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Determination and correlation of solubility of linezolid form II in different pure and binary solvents Determination and correlation of solubility of linezolid form II in different pure and binary solvents](/preview/png/4768107.png)
چکیده انگلیسی
The solubility data of linezolid form II in five pure solvents (water, methanol, ethanol, 1-propanol, 2-propanol) and a binary (water + methanol) solvent were determined among the temperature range from 283.15 K to 318.15 K under atmospheric pressure. The results indicated that the solubility increased with the temperature increasing. Seven thermodynamic models were used here to correlate the experimental solubility data. Through the comparison of the experimental data in pure solvents with the calculated results, we found that the modified Apelblat equation fit the experimental data best. Furthermore, the density functional theory (DFT) calculations showed that the solubility in different solvents related to the interaction strength between the linezolid and the solvent molecules. Finally, the molar enthalpy change, molar entropy change and molar Gibbs free energy change of dissolution of linezolid in the different solvents were also calculated by van't Hoff equation in this paper.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fluid Phase Equilibria - Volume 432, 25 January 2017, Pages 18-27
Journal: Fluid Phase Equilibria - Volume 432, 25 January 2017, Pages 18-27
نویسندگان
Shudan Zheng, You Han, Jinli Zhang, Wei Li,