Sensitivity enhancement of electrochemical biosensor via cobalt nanoflowers on graphene and protein conformational intermediate

The peak current of uHb/Co-GE/GCE is much greater than that of Hb/Co-GE/GCE, suggesting that the greater exposure of the electroactive center and the change of Hb conformation. The entrapped Hb in uHb/Co-GE/GCE is controlled to the most unfolding state, and the electrocatalytic ability of Hb/Co-GE/GCE is extremely improved.162