Bio-compatible eutectic mixture for multi-component synthesis: A valuable acidic catalyst for synthesis of novel 2,3-dihydroquinazolin-4(1H)-one derivatives

Novel derivatives of quinazolin-4(1H)-one derivatives were effectively synthesized via one-pot multi-component reaction of isatoic anhydride, aldehyde and aromatic amines using acidic catalyst in methanol. The catalyst, being a deep eutectic mixture of choline chloride and malonic acid, gave better results than several reported catalysts. Moreover, such eutectic mixtures are cost-effective, recyclable, non-toxic and bio-degradable. The methodology was successfully used for incorporating significant phenyl and heterocyclic substitutions at 2,3-positions of quinazolinone core. In addition, studies related to catalyst screening, substrate variation, recyclability and plausible mechanism of reaction are also described.

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► First report on catalytic use of organic acid based eutectic in one-pot synthesis.
► Catalyst easily derived from choline chloride:malonic acid with 100% atom economy.
► Excellent yields of novel quinazolinone derivatives with varied substitutions.
► The method avoids multi-step synthesis, expensive catalysts and harsh conditions.
► Acid catalyst used is bio-degradable, recyclable, non-toxic and cost-effective.