Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells

Silver-containing silica nanorattles exhibit antibacterial activity against both gram-positive and gram-negative bacteria thanks to the presence of encapsulated Ag and related silver-ion release. The NPs are taken up in an active process by murine immune cells and do not induce production of proinflammatory cytokines and are therefore unlikely to cause inflammation. Therefore, our NPs can serve as promising candidates for fighting biomaterial-related infections.224